smokin’ corona

On my walk home from Kathy’s office this morning, I ran into 3 old girlfriends from work standing in front of the bus stop across from the hospital.  They weren’t waiting for a bus.  None had a job you could do from home (medical assistant X 2, check-in clerk) and yes plenty of patients were still showing up to see their doctors, although efforts were underway to convert many to “virtual” visits.   Talk naturally turned to Mr. coronavirus and I directed them to my blog.  I may have bragged too much about the sufficiencies on Harbal, but none of them followed me through the woods when I finally left and headed home.  We talked about the positive aspects of their current activity.   The lowly smoker is a pariah in the eyes of the U.  Indeed, smoking is illegal everywhere on campus.   Maybe bus stops are havens for which the Ann Arbor city government is responsible and hence provide sanctuary.  But look what these girls gain by their activity: a clean break from work with no screens in sight or job duties creeping in, fresh air, sunshine, social interaction, even laughter.  No wonder the smoker comes back into work with a smile on his/her face.  I wondered aloud whether flooding one’s lungs periodically might even keep Mr. corona from settling there, and vowed I’d check into it once I got home.

Despite my lighthearted comments above, smoking is never a good idea.  With the major morbitity and mortality from COVID-19 being pulmonary, it stands to reason that those who enter into a relationship with the virus will do worse if they’re already starting out with damaged lungs.  But there is surprisingly little addressing this issue in the scientific literature.  

Smoking was a risk factor for development of MERS in Saudis during their 2014 epidemic (as was direct exposure to dromedary camels)(1).  The receptor for the MERS coronavirus was denser in the lungs of smokers than non-smokers, increasing chances the virus would set up shop there (2).  HIV-1 infected smokers have twice the mortality rate as non-smokers, with HIV-1 replication directly promoted by tobacco components (3).  Realize HIV is a much different virus than corona.  So is herpes simplex.  But tobacco seems to inhibit its replication (4).

Big tobacco is in the corona game using the well studied tobacco mosaic virus as a means to  grow in tobacco plants large amounts of certain coronavirus proteins that could serve as a vaccine https://www.politico.com/news/2020/02/15/could-tobacco-cure-coronavirus-115329.  So maybe tobacco will save us after all.  But those cancer sticks aren’t going to do it and now there’s yet another reason to put them away, especially if it’s a Camel.  Sorry, Holly.

But to my friends the smokers, I’ll have to admit they’re drinking up some pretty therapeutic stuff at that bus stop https://medium.com/@ra.hobday/coronavirus-and-the-sun-a-lesson-from-the-1918-influenza-pandemic-509151dc8065

references


1.         Alraddadi BMWatson JTAlmarashi AAbedi GRTurkistani ASadran MHousa AAlmazroa MAAlraihan NBanjar AAlbalawi EAlhindi HChoudhry AJMeiman JGPaczkowski MCurns AMounts AFeikin DRMarano NSwerdlow DLGerber SIHajjeh RMadani TA.  Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014.  Emerg Infect Dis. 2016 Jan;22(1):49-55. doi: 10.3201/eid2201.151340.

2.         Seys LJM, Widagdo W, Verhamme FM, Kleinjan A, Janssens W, Joos GF, Bracke KR, Haagmans BL, Brusselle GG.  DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients.  Clin Infect Dis. 2018 Jan 6;66(1):45-53. doi: 10.1093/cid/cix741

3. Ande AMcArthur CKumar AKumar S.  Tobacco smoking effect on HIV-1 pathogenesis: role of cytochrome P450 isozymes.  Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1453-64. doi: 10.1517/17425255.2013.816285.

4. Larsson PA1Hirsch JMGronowitz JSVahlne A. Inhibition of herpes simplex virus replication and protein synthesis by non-smoked tobacco, tobacco alkaloids and nitrosamines. Arch Oral Biol. 1992 Nov;37(11):969-78.

testing

My dear former English teacher is a constant source of inspiration. She sent me an article about new drive up coronavirus testing in the San Mateo valley. I guess you just drive up, roll down your window, and stick your nose out to have it swabbed by the friendly health care worker in the window. Want fries with that? This triggerred some thoughts.

More making $$$ on the panic.  Hard to get a handle on how much the nasal swab coronavirus tests costs, tho’ the CDC is footing the bill for any public health lab tests and most insurance companies are waiving co-pays.  That doesn’t mean there isn’t a considerable amount of $$ moving between providers and third party payers.  I can’t for one understand the appeal of getting “diagnosed”.  It’s a virus for Christ’s sakes and there’s no f’n treatment.  Stay home, drink liquids, rest, stay away from people.  Is that too complicated?  Wait for the carts “bring out your dead” https://www.youtube.com/watch?v=GU0d8kpybVg

Bye, bye bikes?

I may have slammed the door to ever riding a bicycle again.  Yesterday, I asked Bill at Campus Bike Shop when I could take in my 6 bikes for him to have a look, with an eye to selling them to cash-strapped students in the Spring.  In the meanwhile, I’m covering my bases by contacting my former psychologist and the colleague she thought might help me get over my cyclophobia (yes, that’s the word).  I’ll tell you how I got there later. I still love my bikes.  They hang from my garage ceiling waiting for Kathy and me to take them down and ride them again.  We built up the collection slowly, and it’s well seasoned by now.  I bought my big pale blue Miyata 110 back in the summer of 84 to replace the brown 5-speed Schwinn I’d had since high school.  I’ve replaced just about every piece of standard equipment myself to make it more to my liking.  If a bicycle can fit like a glove, this one sure does.  Next to it hangs Kathy’s blue carbon fiber Trek, light and fast, which she bought with her first big NASA paycheck in ’98, after taking crap from the guides on our Hawaii trip earlier in the year for having such a heavy bike.  Her sturdy reliable red steel number she’d had since college weighed 51 pounds.  Bought a little earlier were our Mongoose mountain bikes when we took the leap into off-roading.  Simple by today’s standards with nary a shock absorber they were always good for a run around the many trails in the area.  Latest additions were the two Specialized combination bikes, which we bought used from Blazing Saddles bike rental in D.C. the second of Kathy’s 4 years there with NASA.  We kept them in the basement of Kathy’s Pennsylvania Avenue apartment and rode them all over whenever I came to visit.  They made errands simple, with a straight bicycle shot preempting having to deal with the Metro.  Bike paths in the area are abundant, and we took our share of long rides.  We brought them home to Ann Arbor, and they became our go to bikes when we didn’t feel like dealing with toe clips or pushing fat tires.

Those bikes have taken us a lot of places.  We used to love riding around town and the surrounding area, back when that wasn’t a hazard.  We learned how well bicycles burned calories.  Whenever I got to feeling a little thick in the middle, I’d get back to my daily 20-25 mile loops and watched it melt away.  We’ve gone through 3 different bicycle rack systems carrying our bikes along to any vacation destination that had any outdoor component .  We took vacations that were exclusively bicycle focused guided by pros.  We’ve circled the Keewenaw, explored the San Juan Islands, ridden around the Big Island of Hawaii, and even pretended to be ace mountain bikers (on bikes we’d bought 2 months previously) on the White Rim Trail in Moab.  We made our own way around the Mission Peninsula, to Canada and back crossing by ferry over lake St. Clair at Harson’s Island and back at Marine City, and I made over 50 miles in one day along Hines Drive to visit my Aunt Dorie in Royal Oak.  We did a century, finishing a hot Helluva Ride one July.  Mercifully, naps along the way were allowed.  But my burning desire was to do it all, over days, without help: strap tent, sleeping bag, cooking utensils, food and water, clothes, and other supplies all to the bike and peddle away.   Adventure Cycling came each month and became like porn to me, with its description of people who had done just what I desired, exploring the corners of the earth.  I finally got Kathy to try something a little like that.  We affixed panniers, loaded them with a few changes of clothes and personal care items and set out to conquer the Waterfront Trail in Ontario.  We started in Niagara Falls, getting there by Via Rail from Windsor and shipping our bikes ahead.  After leaving our B&B there, we made stops at an inn in Niagara-on-the-Lake, a McMaster University dorm in Hamilton, and the Rensselaer Polytechnic Institute student run hotel in Toronto.  Our favorite tragically undiscovered Canadian folk singer, Eileen McGann, was giving a house concert in the Oakville neighborhood, where we ventured by bike – of course – to the marvel of all present, who didn’t believe Americans were capable of such things.

As the new century took on more numbers, we put fewer and fewer miles on our odometers.  We still took our bikes on outdoor vacations, but stopped making bikes the main focus of any extended free time.  Then, in the Fall of ’14, an unsolicited email arrived from Saddle Skedaddle describing a trip in the Lake District of Chile and Argentina https://www.skedaddle.com/us/classicroad/holidays/location/Chile/869#guided

Tho’ it was in and around mountains, it wasn’t really mountain biking.  For the price there should be a lot of pampering, and hey we love malbecs.  It would take place over Christmas break, and we hadn’t yet made any big plans for Christmas, so we signed on.    The weather didn’t permit much training.  After our long same time zone flight to Santiago, then bus to Temuco, we looked around and were pleased: not at all exotic, sort of like the U.P. with volcanoes.  Not long into our first riding day, however, we began to worry we’d made a big mistake.  We rode mountain bikes, not because we were mountain biking but because the local roads were so crappy: big rocks and potholes.  We were clearly the old fat Americans, as everyone else was a trim British or otherwise European Gen-Xer, all riding circles around us.  But there was room for us in the sag wagon, and the lodge at the destination that night was spectacular and served wonderful food, which we happily consumed with our compatriots, who forgave and encouraged us.  The next day was more of the same, and it looked like we’d make lunch without clocking any sag wagon time.  There was a little downhill coming up to be negotiated, which to be safe we were going to take one by one, like Andreas Wellinger at the ski jump.  When my turn came, I surveyed the obstacle: same crappy, potted rocky road, and we seemed to have drawn an audience.  A few locals had come out to watch the foreigners ride down their hill, one woman with 3 little weiner dogs at her side.  If they were like NASCAR fans itching for some spectacular crash, they were about to get their wish.  I rolled down with brakes half applied, bouncing over the rocks I couldn’t swerve past.  Then, as I approached the bottom, one of that woman’s damned little dogs darted into the road, right in front of me.   I squeezed hard.  The bike stopped before hitting the mutt, but I kept going, flying into a nearby ditch landing first on my outstretched right hand, then smack on my shoulder.  The head guide, who boasted some EMT experience, pronounced I had “just a soft tissue injury”, but threw me into the pickup to head to the nearest doctor’s office, just as a precaution.  The doctor’s office, quiet for lunch, did not have an x-ray machine, so we went on to the “German Clinic” in Temuco.  By then, my hand had swelled up, and I couldn’t move it.  Yes, there was pain.  Ernesto, the local bike shop operator Skeedaddle had hired to help with the trip, was along to translate.   I can’t recall which came first, the x-rays or the pain shot.  The x-rays were pretty spectacular and had the techs oohing and aahing.  I’d sustained a fracture through my humeral head and dislocated it for good measure.  They had to call in the local orthopod.  Access to the OR where they’d have to take me to sedate me and pop my shoulder back in was delayed by a young woman going through a difficult delivery with which everyone in entire clinic had to go help.  The young but kindly orthopod finally did his thing, of which mercifully I have no memory.  As I was about to be discharged with my arm in a sling, I asked him why my hand wouldn’t move.  “Brachial plexus injury.  Take about 6 weeks to heal”.  Ah, that intertwining network of “rancid Tom drinks coke” I‘d struggled to memorize back in medical school had been squished by my displaced humerus, where it had rested for the 11 hours between injury and relocation.  Kathy got on the stick and the next day – Christmas – we were flying business class back to Dallas and Detroit.  The long flight gave me plenty of time to strategize, and by Boxing day I was ordering clothes I could handle with one hand and made contact with Dr. Miller, the local shoulder guy.  Had it not been for the accident, we would have missed the Illinois basketball game where Jim Harbaugh was introduced as the new football coach.  I went back to work on the 2nd and never missed a day of work.  Trainees, under my supervision, eagerly did the many procedures I used to do.  The doses of Neurontin I had to take to dull the nerve pain were so stupendous I developed a movement disorder.  I got a medical marihuana card, but found it only distracting rather than useful.   My first useful action with my right hand came in mid-April when I shook the hand of a Londoner who had come up to thank us Yanks for all we’d done for his country.  By June I started wearing “real” clothes again, much to the satisfaction of my chief who had disdained my “unprofessional” look.   By July I was doing meaningful things with my hands again, although the trainees were reluctant to set aside their newly won and much enjoyed activities.  My hand never really made it all the way back.  It still doesn’t feel exactly normal, my fingers don’t straighten all the way, and I can’t use chopsticks.  Although I feel comfortable doing all the hands-on things I used to do, reports have filtered of others seeing “my hands shake” as I aim for a joint with a needle.

So perhaps you can appreciate the memories behind the trepidation I feel when I approach a bicycle.  Clearly “I’ve lost that lovin’ feeling” for bicycles.  Yet that love was so wonderful, so rewarding, for so long, a big part of me wants to try to get it back, if that’s even possible.  Then, each time I knock my head on a hanging bike on the way to the recycle bin, or see the huge expanse of space taken up in my garage by the Yakima bike carrier, I see the practical advantages of just moving on.   I don’t know how my counselling sessions are going to go.  Maybe we’ll even see the scenario where the bikes and rack are all sold before I finally reach a breakthough.  Then I’ll just have to buy me a new one, all modern with all the bells-and-whistles, or maybe even have one custom made to fit my lanky frame.  Regardless, it’ll be cheaper than a Ferrari, and even a little less dangerous.      

Thanks, Bobby

Yesterday, in my post “My Corona”, I suggested this crisis needed a good song and proposed the Knack’s ’79 hit “My Sharona” https://www.youtube.com/watch?v=BR2JtsVumFA. But that tune’s a fire-’em-up number, and I think our times in general need something a bit more calming. I heard one this morning, from ’88, that could do. I’m sure you’ll all remember. Bobby McFerrin sang it for us. Wrote it too. https://www.youtube.com/watch?v=d-diB65scQU

You’re welcome.

Tonic?

After reading yesterday’s blog on corona, my high school English teacher Mrs. Pharriss was particularly taken by the part on possible treatment of the virus with Plaquenil (hydroxychloroquine), derived from quinine. She asked if tonic water might help. I have the answer. This is what I wrote back to Mrs. Pharriss.

Now you’re giving me math assignments!  The dose of quinine to treat malaria is 2-3 200-350 mg tablets 3 times a day.  Likely you’d want to achieve similar levels to kill coronavirus. That’s a daily dose range of 1200-3050 mg/d.  The FDA limits the concentration of quinine in tonic water to 83 mg/liter.  If you assume your quinine water is the strongest allowed by law (Schwepp’s, presumably), you’d have to down 4.4-11 liters, or 1.2-2.9 gallons, per day to achieve therapeutic levels.  If you had that nicely balanced with Tanqueray, you wouldn’t be worrying about Mr. coronavirus anymore. 

My Corona

I submit that what’s missing in this crisis is a good song.  Oh sure, there’s lots of sturm und drang out there, but nothing you can dance to.  And we need a little dancing right now, if only in our socially limited spaces.  Maybe we can resurrect my old high school principal, Hose-Nose Allen, who was adept at patrolling the gym and making sure no one was dancing too close.  These days he’d be making sure masks and rubber gloves were in place.  But I submit there’s already a song out there for all of us, and it only needs a tiny bit of tweaking to bring it 4 decades forward into total relevance to our perilous modern times https://www.youtube.com/watch?v=BR2JtsVumFA.  It’s a high-energy tune, and Lord knows we could use more of that, even if we’re incubating COVID-19, for which a major symptom is fatigue (how can you tell?).  It’s such a fire-you-up song, George W. Bush had it on his iPod.  Probably still does.  After writing all that, and I promise I’m not retracting a word, I found some who has constructed a cute parody around the song for our current crisis https://www.youtube.com/watch?v=jOf1FLxpAGM .  But I say stick with the original and let your mind fill in the corrections.  You may come up with better words than the youtube chika.  And Jeffrey Fieger’s brother Doug, who led the one-hit wonder Knack, probably needs the money.  Who knows how much he gets from a youtube hit?  He’s probably gotten as much from George W. Bush as he’s going to get.

But I wanted to tell you a bit about coronavirus.  I decided a few days back I should actually learn something about it rather that just make snide remarks like “when you wring your hands, wash them before and after”.  Besides having a medical degree and 40 years of practice experience, I was once a virologist.  My masters is in microbiology.   From ’75-’84 I attempted to do research in 4 different virology labs.  I sucked at bench research, but could usually grasp the basic concepts.  So I dove in a few days ago to bone up on the basics of this latest peril to our existence.  I am wearing my white coat, with stethoscope in pocket, as I write this.  So you can trust me.  I’m a doctor.  I wear the white coat more often these days, even though I am retired and not seeing patients, as I want to reassure my dear wife she is living under the same roof as a licensed physician.  With all the fear and trembling being disseminated on campus by Dr. Schlissel and his band of nervous nellies, I figure she needs all the comfort I can provide when she comes home.  A beer, a fire, and a home cooked meal may no longer be enough.

But knowledge is, as they say, good.  Do you care that that the family of our current nemesis got its name because the many protein spikes from its membrane made it look like it had a crown?

Like all viruses, it’s a pesky and clever little critter.   It’s the largest RNA virus.  Influenza, by comparison, is about the same size (50-120 nm vs 100 nm) but has a smaller genome, 14,000 vs 27-32,000 nucleotides.  The human genome is 64,946,660,000 nucleotides.  Measles, herpes, and chickenpox are DNA viruses.  DNA is the stuff of our genes, and needs to be transcribed into RNA to be translated into the proteins that do all the work.  DNA viruses have to follow that same path, sidling up to the enzymes in the cells they invade to do the work, but it’s a couple steps.  The genome of coronavirus is positive strand RNA, so it just comes in, latches up to a few ribosomes (structures that negotiate the whole protein making process) and starts seeing things to its own ends.  Over half the coronavirus genome is devoted to the protein it will use to replicate its own RNA.  What plops out is a big protein molecule that contains within it the power to chop up the rest of itself into two pieces that assemble and become the machine to churn out more little coronaviruses.  Most viruses bring their own nucleic acid replicating enzyme with them.  But corona just asks the host to whip them up a fresh one.  Coronas aren’t content to just penetrate a cell, they hone to the Golgi apparatus, a membrane bound transport system deep inside for shuffling proteins about the cell.  There are 9 proteins in the coronavirus that do different things.  The spike protein that makes up the “crown” has the property of looking to immune proteins like a nice place to settle their “Fc” portions.  Immune proteins have an “Fv” portion that recognizes various foreigners and the “Fc” portions where it just settles in.  So immune proteins coming to attack Mr. coronavirus just turn tail and settle in instead, and nothing happens.  Its main purpose is to latch onto cells to invade, and it is the structure to be mimicked by any vaccine that’s being developed.  Other proteins help it get in and out of the cell it’s infected.  Transcription of the viral RNA proceeds willy nilly with none of the proof reading that usually accompanies nucleic acid synthesis.  As a result, the error rate in reading coronavirus RNA is about 1/10,000 nucleotides.  With an average 30K genome, that translates to 3 mutations per replication.  So making new Mr. coronaviruses is a pretty shaky proposition, and why they can sometimes turn dangerous, from common colds to SARS.

Coronaviruses account for about a third of all common colds.  Testing for coronavirus has been available on “respiratory panels” for years, but few doctors test as there’s nothing to do for these viral diseases.  A couple of times this century, coronavirus has mutated to get out of hand and cause trouble.  In 2002 Severe Acute Respiratory Syndrome (SARS) emerged from China and quickly spread to the US, South America, Europe and Asia before it was controlled. During the 2002-2003 outbreak, 8,096 people were confirmed as infected and 774 died.  In 2012, people began dropping in the Arabian peninsula to Middle East Respiratory Syndrome (MERS). Of 2,494 laboratory confirmed cases, 858 died (34.4% fatality rate).   Fortunately, MERS never travelled.  When Chinese peasants began dropping in Wuhan province last December, the virologists at the conveniently located Wuhan Virology Institute were all over it.  The unfortunate folks with severe respiratory disease not responding to usual measures who had all just been at a local fish market harbored a coronavirus, sharing 79% of its RNA with the nasty agent that had cause SARS.  That was enough to make them the same species.  The host animal was the local bat, who carried the same thing.  They named their find ”2019-nCoVBetaCoV/Wuhan/WIVo4/2019” or 2019-nCoV for short.  So those complaining that calling this the “Wuhan virus” is somehow disparaging to our Chinese friends should note that this is what their own scientists designated.  Nowhere in this report can I find any red flags saying this virus is some sort of Andromeda strain.  Maybe the similarity to the original SARS virus has been enough to trigger the sort of insane response we’ve seen to date.  It is easily transmissible by human-to-human contact.  Stats to date say the fatality rate (about 1%) is worse than the flu (0.1%) although way more people get the flu every year than are ever going to get this coronavirus.  I had hoped that diving into the science would give me a better understanding of the panic.  Alas, it has not.

But I have been encouraged by some recent developments.  One of my favorite former nurses sent me this video about some new findings regarding possible treatment.  It turns out that a drug I once prescribed by the barrel full – Plaquenil (hydroxychloroquine, a quinine extract from cinchona bark) – does a bang up job of inhibiting coronavirus replication in the test tube.  The concentrations needed to achieve this effect are similar to those reached by standard dosing of the drug for other conditions (rheumatoid arthritis and lupus)   https://www.youtube.com/watch?v=vE4_LsftNKM&feature=share.  Other drug combinations are being tried, particularly using some of the anti-HIV drugs.  Before AIDS, there wasn’t much attention to anti-viral therapies.  So I have supreme confidence a treatment will emerge, and soon.

And as we seek to endure, the great CS Lewis provided words long ago which speak to our situation.  Let us heed them. https://www.thegospelcoalition.org/article/cs-lewis-coronavirus/

references

Hunt R. Corona viruses, colds and SARS. in Microbiology and Immunology On-line, Hunt R, Editor. University of South Carolina School of Medicine. http://www.microbiologybook.org/virol/coronaviruses.htm

Zhou PYang XLWang XGHu BZhang LZhang WSi HRZhu YLi BHuang CLChen HDChen JLuo YGuo HJiang RDLiu MQChen YShen XRWang XZheng XSZhao KChen QJDeng FLiu LLYan BZhan FXWang YYXiao GShi ZL. A pneumonia outbreak associated with a new coronavirus of probable bat origin.  Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7

Miles from Nowhere

A dear friend who had just almost lost her ear to skin cancer surgery sent me diving into the Cat Stevens songbook seeking the tune about losing body parts (Moonshadow, it turns out: https://www.youtube.com/watch?v=9c49aDWrzeA) and got me reveling in his first albums that somehow we all adored in the midst of all that heavy rock and psychedelia of the early 70s.  It’s still absolutely wonderful music and I got through Mona Bone Jakon and a good part of Tea for the Tillerman till my Airbuds pooped out as the 353 Wolverine rocked and rolled towards Ann Arbor from Chicago.  I might have gotten to the Indiana border.  Tears came more than once but I think Kathy was shocked when I turned my tear streaked face to her and held my phone up to show her a song I want to be played at my funeral.  Now I had been deep into the emotional pit that Cat is so good at making by then, all through Mona Bone Jakon and 5 cuts into Tea for the Tillerman. And he’s pretty good at those universal truths.  But these hit home.   Let me tell you how. https://www.youtube.com/watch?v=2rEylPTqPxo

Miles from nowhere
I guess I’ll take my time
Oh yeah, to reach there

The little Village I grew up in, Vicksburg, was miles from nowhere. I’ve always taken my time getting to things.  I didn’t declare a major till my junior year at Michigan, and even then it was a thrown together thing, putting medical school – if attained – at least a year past my graduation.  I kept on pace for the 4 year grind at U of C, but went back to tapping the brakes at Barnes.  My misbehavior put a year pause between finishing residency and starting fellowship at Michigan.  I didn’t get married till I was 34.  They had to petition to extend my tenure clock at Michigan.  Now retired, I fully intend to take my time to get to the next there.

Look up at the mountain
I have to climb
Oh yeah, to reach there.

I haven’t had an easy climb since I left Vicksburg.  Keeping grades up at Michigan was a grind.  Trying to scramble up and make something at bench research was a struggle at which I tried and failed for 9 years.  God, how U of C was a grind, even knowing it was next to impossible to flunk out.  Thrown in with the best and the brightest at Barnes was a constant struggle to keep up.  At Michigan, the reach always exceeded the grasp.  Tenure, o.k., but that next climb to “fool” professor just wasn’t going to happen.  I made Emeritus, which means they no longer pay you. I give them value for their dollar. The mountains there to climb in retirement will be of my own making, so I’m looking forward to scaling those, whatever they happen to be.

Lord my body has been a good friend
But I won’t need it when I reach the end

My body and I have had a lot of good times, and I’ve taken care of it, mostly. I think it has a few miles, and good times, left to go. But when I’m done, God and Jesus are taking over.

Miles from nowhere
Guess I’ll take my time
Oh yeah, to reach there

I creep through the valleys
And I grope through the woods
’cause I know when I find it my honey
It’s gonna make me feel good

I found my honey 36 years ago, after a lot of groping, and boy does it still feel good.

I love everything
So don’t it make you feel sad
’cause I’ll drink to you, my baby
I’ll think to that, I’ll think to that.

Sure do.  And I’ll drink to most anything.

Miles from nowhere
Not a soul in sight
Oh yeah, but it’s alright

I’ve spent long stretches of my life alone. I was on only child, so being by myself seemed a natural state. After my mother died, I was the big fat kid nobody wanted to play with. Not till Vicksburg did I feel part of a group. At great big Michigan, I swam alone in a sea of strangers. I fondly recollect a few people from Hyde Park, but mostly I was by myself in that cold gray place. I learned in St. Louis that if you chased women successfully, you’d be pretty much assured of company. But even that system did not always work. My last year there, I lived in a 16th floor penthouse overlooking Forest Park. Sometimes, it was lonely at the top. Back in Ann Arbor, I found my second family in the Division, and of course my future bride. Yet, I was never embraced by the serious types, worse toward the end. Ten years ago, I discovered my biological family and now have more relatives than I can remember. I have friends spanning 55 years, mainly from Vicksburg. I don’t get lonely anymore. When I do find myself alone, I have many years of practice on how to keep myself company. Don’t cry for me.

I have my freedom
I can make my own rules
Oh yeah, the ones that I choose

Now that I’m retired, yeah.  Oh, yeah.  Never tasted freedom like this until now.  So sweet.

Lord my body has been a good friend
But I won’t need it when I reach the end

Miles from nowhere
I Guess I’ll take my time
Oh yeah, to reach there.

Docere

Some years ago, as my Kathy was emerging from her NASA.years, she formed an LLC mainly to collect the proceeds from her speaking gigs.  More recently, it is collecting the royalties from the on-line textbook she wrote about her Kinesiology subject of 9 years, Scientific Writing.  After my retirement, I asked her to add me.  Someone might end up paying me for writing, consulting, or even patient care.  Plus it provided an excuse for new business cards and stationery, for which my old forms were now obsolete.  As I described our new venture to my dear high school friend Rod Taft, he asked what our main product was.  I replied “knowledge”, which, you know, is good.  This evening, as partners we sat before the fire, we decided some additional description might be necessary for out post-retirement venture, Kathy’s still to begin.   Kathy found the word “Luxuria sed implemini”, in seeking the Latin term for debauchery.  We’ll call our lawyer tomorrow.  By the way, docere comes from the Latin “to teach”.

feed my worms

Vermiculture, they call it.  Basically, you keep some special worms in a box somewhere in your house, feed them your non-meat kitchen scraps, and get rewarded with a nice treat for your garden. Kathy and I tried it years ago, even using few scoops of their product, but then fell out of the habit of feeding them, so the little dears all left us after a final orgy of copulation, cannibalism, starvation, death and decay.  We finally got over the guilt and decided to try it again, promising to be more attentive to their needs.  We still had the gear.  The box was pristine, rather remarkable considering the debacle that preceded.

We had the 1.3 gallon stainless steel bucket to sit, virtue signaling, in our kitchen to collect the scraps until feeding time.  You can’t get ‘em that look like this anymore, at least not on Amazon.

More important than hardware, we had the software, the little book by Mary Applehof of Kalamazoo that explains it all.

The next soft piece we needed was the worms themselves.  You need a special worm for this task.  Walt’s crawlers just won’t do as they’re too big, don’t poop enough, and are sold by the dozens not the hundreds.  The best critters are “red wigglers”, or redworms, as more boring people call them.  Scientists call them Eisenia fetida and yes, you Latin scholars out there will smell a shared root in the species name.  Apparently, sometimes these darlings can get a little stinky in large numbers from the voluminous output that makes them such good composters.  We did not sense that problem is our first go around with them, even during their denouement.  But where to get them?  I figured that in earth-conscious Ann Arbor there would be a redworm farmer, but none I could locate.   On the net I easily found Uncle Jim’s Worm Farm in Spring Grove, Pennsylvania.

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Jim (who doesn’t list his last name) started raising worms for fishermen back in the early 70s, turned to the redworm and composting in the 80s and never looked back.   He was happy to sell me 500 wigglers, which arrived 2 days later.

That started the serious clock, and it’s a short one. The little buggers don’t last more than 2 days, after which things are iffy even with heroic measures.  We had to embark on the difficult part of the whole venture.  You can’t just set the worms on the floor of their new home and feed them their first meal.  There lies suffocation, compaction or both.  The new worm farmer must provide a soft bed to his clew.  Mary Applehof says 5 pounds of shredded newsprint would do the trick for my 1.6 cubic foot Worm-a-way bin.  Panic?  Close!  Who has that much newspaper laying around anymore?  I used to faithfully bundle up my old newspapers for collection at the curb, but the modern throw-in-everything compost bin has done away with that practice.  And anyway, who gets newspapers anymore?  I frantically called around.  I had dying worms depending on me.  My local grocery store had yesterday’s unsold papers laying around, which they would be happy to sell me at face value.  They recommended I wait till Monday, when I would get more newspaper for my dollar as the unsold Sunday papers would be bigger.  Most other numbers my net search found just didn’t answer.  Fortunately, I found the Washtenaw News Agency, which sold bundles of unsold New York Times for a buck each.  That would be my best value on the  Times since they stopped running coupons.  People liked to buy them for their pets, she said.  Me, too, I thought.  I told her my worm story and she was amused.  When I picked up my 11 pound bundle, she offered her thought on how smart my worms would be.  Looking at the papers, from the last 3 days of January and featuring lurid color depictions of the players in the last days of the impeachment thing, I hoped my worms would have a sense of humor.

Unlike real farmers, worm farmers don’t do any actual physical labor.  That is, except for preparing the bedding.  Turning a 5 pound stack of newspapers into a pile of separate 2 inch strips is equal parts arduous and tedious.  An unfolded Times is 12 inches wide and 24 inches long.  Taking my box cutter to a folded section, I could free a strip with a couple swipes from each side. Then I had to peel each strip off one by one to make a fluffy pile in the bin.  Kathy soon joined me and decided she needed a meaner weapon.  She descended to her sewing room and brought up with her a Fiskar Classic Stick Rotary Cutter, or “pizza cutter” as she likes to call it.  I believe the paste in function puts wide open areas around it for our protection.   

This bad boy made short work of those Times.  In sharing this chore for our animals, I began to understand how those farm couples stayed so close.  As we prepared their beds, we mused over our hermaphrodite worms that would soon frolic there, proud of the acceptance of their orientation and sexuality we would show them.  So Ann Arbor.

The bed was made before the worms’ clock went off.  We ladled them on, kept the box top off with a bright light on, which drives them deeper into the bed, then put the top on and carried them to their new perch downstairs.  The compost bucket was already bursting, and I lovingly carried it down later that evening, feeding them their first meal in their new home.  We have been faithful in refilling the bucket, and have even generated a second feeding since the worms came.  I hope Kathy and I can keep up our new good habits.  During my first stab at vermiculture, I liked to answer those who asked if I had any pets “well, I have a thousand worms downstairs”.  I intend to resurrect that retort, this time adding “and they’re well fed”.