why rheumatology and, um, death?

I thought after all this coronavirus stuff, we needed a light break. As is often the case these days, this one was inspired by my high school English teacher Mrs. Pharriss. Towards the end of a long e-mail, she asked me: “Did you have to deal with deaths of patients very often during your medicalContinue reading “why rheumatology and, um, death?”

How Plaquenil May Work

I struggled for 36 years in Rheumatology to figure out how Plaquenil works in our diseases, and never did.  But I think I might understand, at least in part, how it’s working in its new role as our savior from Mr. coronavirus. It’s just a matter of simple chemistry.  OHC (hydroxychloroquine: Plaquenil) accumulates in acidic intracellular organelles,Continue reading “How Plaquenil May Work”

The Chinese COVID-19 Guidelines March 4th

The Chinese Health and Public Health Ministry Guideline on Novel Coronavirus Disease (COVID-19) Diagnosis and Treatment (revision #6) was released in Beijing March 4th.  The guideline derives from experiences in treating over 80,000 Chinese patients.  The document has been translated from Mandarin and stealthily but broadly circulated for about a week. Dr. Ainlin Xu, anContinue reading “The Chinese COVID-19 Guidelines March 4th”

Plaquenil for corona

My Saturday post mentioned initial findings that the old anti-rheumatic drug Plaquenil (hydroxychloroquine) may have some significant activity against coronavirus. The Chinese Health Ministry guidelines on coronavirus have been stealthily and widely distributed. I saw both versions (translated and Mandarin) the same Saturday I made my post. The guidelines even made it to a GPContinue reading “Plaquenil for corona”