0-micron don’t worry, be happy

I’m usually not one to post extensive work from someone else. But this piece addresses concerns about the new variant (1). Bottom line, it isn’t even going to be very infectious. Prior vaccines aren’t going to help much. Boosters are nonsense and probably dangerous by instigation of antibody dependent enhancement (ADE) (2)

Here’s the post:

French Research and Real-World Data Counter Omicron Hysteria

So much talk about Omicron; so much fear-mongering; so much talk about science.  Most is nonsense.  The best research has received little attention.  It comes from esteemed, senior French scientist: Dr. Jacques Fantini, Professor of Biochemistry and Molecular Biology at the University of Aix-Marseille.

You are about to learn what senior people in the public health establishment need to use, especially Fauci who claims he speaks for and represents “science.”  If he knows the French research, he is not sharing it with the public, nor is the mainstream media.

The key scientific achievement by Fantini is the calculation of one key parameter he calls the index of transmissibility (T) of a COVID variant.  The key work was published in June 2021 with the title “Structural dynamics of SARS-CoV-2 variants: A health monitoring strategy for anticipating Covid-19 outbreaks.”  This research is very sophisticated, detailed and challenging.  Genomic sequence data are used in the analyses of variants.

The molecular details of variants are analyzed to calculate T values for COVID variants.  Originally, T values for known variants or strains of the COVID virus were determined.  The T value for the Delta variant done in early 2021 accurately predicted the surge of Delta throughout the world, making it the dominant variant in many countries, including the US.

The T value accurately describes to what extent a variant is or is not very transmissible.  The higher the value of T, the greater is the ease at which a variant is spread from one person to another.  The higher the value, the more contagious is the variant.  Fantini said how T values could serve a critical need: “T-index can be used as a health monitoring strategy to anticipate future Covid-19 outbreaks.”  At this moment, the question is “Is the T value for Omicron of concern?”

So, now look at the following table that gives T values for the original five variants published by Fantini, plus what he has just released for the new Omicron variant.

VariantT-index
Initial Wuhan2.16
UK – Alpha3.59
Brazil – Gamma3.65
South Africa – Beta3.82
Delta10.67
Omicron3.90

Delta stands out for having an extremely high T value compared to previous variants.  

No surprise that it quickly became the dominant variant globally.

And equally impressive is the relatively low T value for Omicron, just 37% of the Delta value.  Omicron should not be of high concern by people and nations.  It is in line with most pre-Delta variants.  It is not exceptional.  There is no scientific basis for all the hysteria about Omicron.  As shown below, most people assessed with Omicron were vaccinated and got breakthrough infections showing vaccines offer little protection.

Additional observations

Note that the higher the T value it is also likely the less effective are current vaccines for defending against the variant and protecting people from it (as real-world data given below show).  However, the higher T value does not imply greater lethality.  As is known by virologists, variants are smart enough to not kill their victims, which would also kill them and prevent them from spreading.  Thus, high T value variants spread easily, can cause health impacts but do not necessarily kill people at a high rate.

Fantini said this: “For Omicron, the mutations go in all directions, without any particular logic, some annihilating each other.  The mutational profiles …suggest that neutralizing antibodies [from vaccine immunity] will have very low activity on this variant.  …This analysis of the Omicron variant suggests that this variant will not supplant Delta.”  In other words, with far less spreading potential, Omicron is not likely to replace the much higher transmissible Delta prevalent globally.  Even though reports keep coming in from different nations that Omicron has been found.

More positive insights had to do with the more than 30 mutations and exactly where they were located in the molecule.  “The affinity of the Omicron … for ACE-2 [cellular material that causes infection] is decreased compared to all other variants analyzed to date, probably as a consequence of this accumulation of mutations.”  Fantini is saying that Omicron is not only not as highly transmissible as Delta, it is also not as infectious.

Worth remembering is that all the current COVID vaccines were designed to address the earliest COVID virus molecule.  Thus, they do not protect very well against later variants that have considerable mutations.  Is protection zero?  No.  Current vaccines offer limited defense against variants because they only aim at a small fraction of the virus molecule components.

Vaccine problems

In a more recent article, Fantini and an associate said: there is a “progressive loss of immunity induced by the two doses of vaccines directed against the spike protein” because current vaccines are not designed to defend against recent variants, including Delta and Omicron.  Moreover, “the third vaccine [booster] dose can have serious long-term side effects due to the “ADE” phenomenon (Antibody-dependent enhancement: facilitation of infection by antibodies).  The benefit/risk ratio would be unfavorable.”  In other words, like other researchers, they see the negative impact of current COVID vaccines that reduce protection offered by a person’s immune system. What is being said is that antibodies not only offer little protection but, instead, facilitate viral infection and promote release of new mutations or variants.  

This is consistent with considerable data showing correlations between higher vaccination rates and higher death rates at the nation level.

This too was noted: “The immune response to SARS-CoV-2, whether natural or vaccine-induced, produces antibodies directed against the spike protein.  In the case of mRNA vaccines, the only molecular target is the spike protein.  In the case of natural infection with the virus, the immune response [natural immunity] is directed against several viral proteins, including the spike protein.  In all cases, the spike protein is therefore crucial.  However, SARS-CoV-2 is an RNA virus that mutates a lot, and many mutations affect the spike protein, which disturbs its recognition by antibodies.”  The bottom line is that vaccine immunity is inferior to natural immunity, because the former was designed for the earliest strain and only targets a small fraction of the complex COVID molecule.

Real world data show no severe illness and no protection from vaccines

The forecast by Fantini about Omicron is consistent with information flowing in.  Specifically, vaccines will have little impact on Omicron transmission or infectivity.  

For example, Reuters reported: “Four people in southern Germany have tested positive for the Omicron COVID-19 variant even though they were fully vaccinated against the coronavirus said officials.”  Moreover, “All four showed moderate symptoms.” 

Previously it was highlighted, according to the Botswana government, the Omicron variant was first detected in four people who were fully vaccinated.  And information from South Africa is that Omicron caused mild symptoms and no patients needed hospitalization, and that the European Union’s public health body said that they’ve found 44 cases containing the omicron variant in 10 of their member countries, all of which had mild or asymptomatic illness.”

Also reported was that “Two quarantined travelers in Hong Kong who have tested positive for the variant were vaccinated with the Pfizer jab.  All three initial confirmed and suspected cases reported from Israel occurred among fully vaccinated individuals.  And an Israeli doctor revealed that he had been infected with Omicron despite being triple vaccinated also wearing a mask.

In Australia, “New South Wales state authorities reported that two travelers from South Africa to Sydney had become Australia’s first omicron cases.  Both were fully vaccinated, showed no symptoms.”  A person in San Francisco was reported to have traveled from South Africa, had mild symptoms and had been vaccinated.  

Interestingly, officials said they had contacted everyone who had close contact with the person and they had all tested negative.

Meanwhile, everything that Fauci has said is completely inconsistent with actual data as well as what Fantini has forecast.  Everything he has said seems clearly aimed at instilling fear about Omicron so that invasive, authoritarian government actions and continued push for vaccines could be justified.

Conclusions

review of studies found unequivocally that COVID vaccines do not stop viral transmission, with no difference between vaccinated and unvaccinated people.  So, all real-world evidence is that Omicron cannot be effectively addressed by COVID vaccines.  Together with Fantini’s work the proper conclusion is that Omicron will not be very transmissible nor be more infective than Delta.

Because mutations will continue to produce variants, it is critically important to use the work of Fantini.  To accurately assess whether or not a new variant should evoke the fears and government responses that have sprung up so quickly for Omicron.

By Dr. Joel S. Hischhorn

And of course, we can always stand to hear the comments of Bobby McFerrin (3).

Dr. Joel S. Hirschhorn, author of Pandemic Blunder and many articles and podcasts on the pandemic, worked on health issues for decades, and his Pandemic Blunder Newsletter is on Substack. As a full professor at the University of Wisconsin, Madison, he directed a medical research program between the colleges of engineering and medicine.  As a senior official at the Congressional Office of Technology Assessment and the National Governors Association, he directed major studies on health-related subjects; he testified at over 50 US Senate and House hearings and authored hundreds of articles and op-ed articles in major newspapers.  He has served as an executive volunteer at a major hospital for more than 10 years.  He is a member of the Association of American Physicians and Surgeons, and America’s Frontline Doctors.

Comments

https://jetpack.wordpress.com/jetpack-comment/?blogid=180848223&postid=14882&comment_registration=0&require_name_email=0&stc_enabled=1&stb_enabled=1&show_avatars=1&avatar_default=identicon&greeting=Comments&greeting_reply=Leave+a+Reply+to+%25s&color_scheme=light&lang=en_US&jetpack_version=10.4-beta&show_cookie_consent=10&has_cookie_consent=0&token_key=%3Bnormal%3B&sig=431de6a01215b6236b9701cac7877112531bdc02#parent=https%3A%2F%2Fthebluestateconservative.com%2F2021%2F12%2F03%2Ffrench-research-and-real-world-data-counter-omicron-hysteria%2F

References

  1. Hischorn JS. French Research and Real-World Data Counter Omicron Hysteria. The Blue State Conservative. December 3, 2021. https://thebluestateconservative.com/2021/12/03/french-research-and-real-world-data-counter-omicron-hysteria/
  2. Ike B. ADE. Word Press. November 23, 2021. https://theviewfromharbal.com/2021/11/26/ade/1.
  3. Ike B. Thanks, Bobby. Word Press. March 15, 2020. https://theviewfromharbal.com/2020/03/15/thanks-bobby/

Published by rike52

I retired from the Rheumatology division of Michigan Medicine end of June '19 after 36 years there. Upon hitting Ann Arbor for the second time (I went to school here) it took me almost 8 months to meet Kathy, 17 months to buy her a house (on Harbal, where we still live), and 37 months to marry her. Kids never came, but we've been blessed with a crowd of colleagues, friends, neighbors and family that continues to grow. Lots of them are going to show up in this log eventually. Stay tuned.

12 thoughts on “0-micron don’t worry, be happy

  1. Absolute trash! Absolutely no proof. All theory and all nonsense as well as extremely dangerous. What kind of “Dr.” Is he.

    Like

    1. You know what is dangerous? Pushing the Pfizer clotshot which FDA data shows has higher all cause mortality than placebo and no statistically-significant benefit against covid mortality. And the vaccine manufacturers have exemption from legal liability and there have been no long term safety studies on humans of the covid vaccines.

      Where did you earn your degree? The Caribbean?

      Liked by 1 person

      1. Perhaps you were referring to Dr. Britton. I found a Lee Roy Britton who’s a 79 year old surgeon in Alpena, Michigan. Surely on the cutting edge. His Instant Checkmate entry doesn’t say where he went to med school.

        Like

      2. Yes, I was replying to Britton. Very few doctors have done their due diligence and actually read the science. If they have looked at any articles, most are abstract-skimmers. Most doctors just repeat propaganda from the CDC and FDA.

        The FDA was recently forced to release its raw data on the Pfizer clotshot, which showed 1223 deaths and over 9,000 “unknown” results…out of 44,000 trial participants, that’s a huge loss to follow up. And the deaths roughly correlate to VAERS reports, which number 3,000 odd for Pfizer. Of course, some of the unknowns are likely deaths, but we don’t know how many yet. Blinding may prevent our ever knowing.

        The covid vaccines have been a total cluster….what kind of fool would ever recommend taking a covid vaccine? Oh, yeah, a brainwashed member of the vax cult. Duh.

        Like

  2. Amen, brother. I earned my MD from the elite University of Chicago, trained in medicine at the incomparable Barnes Hospital in St. Louis, took a fellowship in rheumatology into a faculty slot, eventually tenured, at the University of Michigan. My education has been peppered from grad school through my fellowship
    with virology research. I think I know what I’m talking about here.

    Liked by 1 person

    1. No medical training here.

      I have probably read a thousand journal articles or so on covid, myself. I’m not an abstract skimmer and I have no trouble understanding the articles. I have degrees in physics and chemistry, so I had to look up the jargon at first (like DIC…disseminated intravascular coagulation). With my physics training, I can speak about mask dynamics better than doctors and I laugh at the doctors who publish review articles about masking in JAMA.

      The few people who follow my blog are mostly retired doctors.

      I found myself in almost 99% agreement with Harvey Risch on almost all aspects of covid. His expertise in biostatistics adds a lot of weight to his analysis, especially when he looked at studies of HCQ.

      Like

  3. Dear Bob

    Hello from the UK. Thank you very much for this post. I have a BSc in Land Management, I am a Chartered Building Surveyor (retired hurt due to facial palsy and side issues due to sodium nitrite (E250) poisoning leading to nitrosamines) with a career in defect diagnosis over nearly 40 years.

    So, whilst I have no medical training as such last year I managed to work out that in fact vaccines are utterly pointless against anything, and always have been. I used to think they were of some use and have had my fair share over the years.

    In any event, I know you know what you are taking about, although perhaps you may not be aware that omicron is an anagram of moronic.

    I have done a post on the variants which may be of assistance. Please note I do use humour to lighten the mood and to help make the points.

    https://alphaandomegacloud.wordpress.com/2021/12/02/various-variants-covid-19/

    This may also be of interest.

    https://alphaandomegacloud.wordpress.com/v-is-for-vaccination/

    Kind regards

    Baldmichael Theresoluteprotector’sson

    Liked by 1 person

    1. Thanks so much for connecting! I enjoyed your post on the variants so much I put it as a link on my own page. You know our overfunded CDC does its own characterization of “variants” with a fairly precise nomenclature that reveals their lineage https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-classifications.html. Then we go ahead and use the WHO names, which I guess are simpler and sexier, especially with the links to classic aircraft. Are they employing a marketing firm or are you doing this for them for free? Keep up the good work and keep in touch.

      Liked by 1 person

      1. Many thanks and I will look at the link you mention. I do everything for free, for those I call the children of God in the hope they will laugh.

        The hypnotic spell they are under will be broken and, like story the prince who kisses the sleeping beauty, they will wake up.

        However, considering my facial palsy makes me rather lopsided, and my bald head and long lockdown hair, they may wish they had never bothered!!!

        Yours, Baldmichael

        Like

Leave a Reply to rike52 Cancel reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: